林榮辰

  • 發布日期：115-06-05
  • 更新日期：115-06-29
  • 發布單位：牙醫學院
林榮辰
 
林榮辰 (Jung-Chen LIN) 助理教授

電子郵件：linjungchen@nycu.edu.tw

聯絡電話：02-2826-7314

辦公室位置：牙醫館 313 研究室

專長：免疫工程、仿生材料、口腔免疫學、生物化學
 
學歷：
  • 2014：國立台灣大學醫學院免疫學研究所 博士
  • 2004：國立陽明交通大學牙醫學院口腔生物研究所 碩士
經歷：
  • 2024/08 – 迄今：國立陽明交通大學牙醫學院 口腔組織工程暨生技材料研究所 專任助理教授
  • 2022/02 – 2024/07：國立陽明交通大學牙醫學院 口腔生物研究所 兼任副教授
  • 2016/02 – 2024/07：中央研究院生物醫學研究所 博士後研究學者
  • 2015/02 – 2017/07：國防醫學院病理及寄生蟲研究所 兼任助理教授
  • 2015/01 – 2016/01：國防醫學院病理及寄生蟲研究所 博士後研究員
  • 2015/01 – 2015/12：匯德生物科技股份有限公司研發部 研發長
  • 2014/09 – 2014/12：國立台灣大學醫學院免疫學研究所 博士後研究員


榮譽成就
 
  1. 第33屆王民寧獎:優秀論文獎—財團法人王民寧先生紀念基金會頒發 (2023)
  2. 傑出論文獎—第六屆國際再生醫學材料研討會暨台灣生物材料與控制釋放學會年會頒發 (2023)
  3. 111年度博士後研究人員學術研究獎—科技部頒發 (2022)
  4. 研究生優秀著作獎—國立台灣大學醫學院頒發 (2014)


研究方向

用於免疫工程和免疫調節的仿生生物材料


近五年研究計畫
研究計畫名稱 擔任之工作   起訖年月   補助單位
Development of mechano-activation to enhance T cell function via modular rigidification
of intracellularly polymerized dendritic cells		 主持人 2025/01/01~
2027/12/31		 國科會
Dissecting the impact of facultative anaerobes and obligate anaerobes on oral epithelial
cells and osteoblasts using intracellular hydrogel technology		 共同主持人 2025/08/01~
2027/07/31		 國科會
Targeting resistance-associated metabolic and molecular cues to facilitate chemo/radio
therapeutic sensitivity in oral cancers		 共同主持人 2025/08/01~
2026/07/31		 國科會


近五年代表著作

(＃共同作者)
  1. Hsu, C.Y., Tsai, P.C., Lin, J.C., Pai, C.H., Teng, Y.J., Yao, B.Y., Fei, C.Y., Shiau, G.H.M., Lin, L.C.W., Yang, H.C., Hu, C.M.J.*. 2025. Biomimetic Lymphocyte Capture by Polymer-Stabilized Superparamagnetic Antigen Presenting Cells Enriches Tumor-Reactive T cells and Improves Neoantigen Identification. Nat Commun 16 (1):5088 (IF=16.1; 8/134; Q1)
  2. Baghdasaryan, O.#, Khan, S.#, Lin, J.C.＃, Lee-Kin, J., Hsu, C.Y., Hu, C.M.J.* and Tan, C.* 2024. Synthetic control of living cells by intracellular polymerization. Trends Biotechnol 42(2):241-252. (IF=17.3; 3/158; Q1)
  3. Lin, C.L.; Fang, Z.S.; Hsu, C.Y.; Liu, Y.H.; Lin, J.C.; Yao, B.Y.; Li, F.A.; Yen, S.C.; Chang, Y.C., and Hu, C.M.J.* 2024. Rapid plasma membrane isolation via intracellular polymerization-mediated biomolecular confinement. Acta Biomater 173:325-335. (IF=9.7; 6/96; Q1)
  4. Chien, C.Y.＃, Lin, J.C.＃, Huang, C.Y., Hsu, C.Y., Yang, K.C., Chattopadhyay, S., Nikoloutsos, N, Hsieh, P.C., and Hu, C.M.J.* 2023. In situ hydrogelation of cellular monolayers enables conformal biomembrane functionalization for xeno-free feeder substrate engineering. Adv Healthc Mater e2201708. (IF=10; 8/96; Q1)
  5. Yang, K.C., Lin, J.C., Tsai, H.H., Hsu, C.Y., Shih, V, and Hu, C.M.J.* 2021. Nanotechnology advances in pathogen- and host-targeted antiviral delivery: multipronged therapeutic intervention for pandemic control. Drug Deliv Transl Res 11(4):1420-1437. (IF=5.4; 43/136; Q2)
  6. Lin, J.C., Hsu, C.Y., Chen, J.Y., Fang, Z.S., Chen, H.W., Yao, B.Y., Shiau, G.H.M, Tsai, J.S., Gu, M., Jung, M.Y., Lee, T.Y., and Hu, C.M.J.* 2021. Facile transformation of murine and human primary dendritic cells into robust and modular artificial antigen-presenting systems by intracellular hydrogelation. Adv Mater 33 (30):2101190. (IF=29.4; 5/178; Q1)


專利
 
  1. Internally fixed lipid vesicle (I653990, Taiwan)  2019/03/21   
  2. Peptide-loaded carrier system and uses thereof (PCT/US2020/043963)  2021/02/04   
  3. Method for natural killer cell expansion (I784426, Taiwan)  2022/11/21 
  4. Artificial antigen presenting cell system and uses thereof (TW202208618A)

Contact Information:

ORCID ID: 0000-0002-0791-0985
Scopus Author ID: 57190767803

Research Interests:

林榮辰老師實驗室

 


其他著作
 
  1. Chattopadhyay, S, Liu, Y.H., Fang, Z.S., Lin, C.L., Lin, J.C., Yao, B.Y., and Hu, C.M.J.* 2020. Synthetic immunogenic cell death mediated by intracellular delivery of STING agonist nanoshells enhances anticancer chemo-immunotherapy.Nano Lett 20:2246-2256. (IF=10.8; 21/178; Q1)
  2. Lin, L.C.W., Huang, C.Y., Yao, B.Y., Lin, J.C., Agrawal, A., Algaissi, A., Peng, B.H., Liu, Y.H., Huang, P.H., Juang, R.H., Chang, Y.C., Tseng, C.T., Chen, H.W., and Hu, C.M.J.* 2019. Viromimetic STING agonist-loaded hollow polymeric nanoparticles for safe and effective vaccination against middle east respiratory syndrome coronavirus. Advanced Functional Materials 29(28):1807616. (IF=19; 8/178; Q1)
  3. Lin, J.C.＃, Chien, C.Y.＃, Lin, C.L.＃, Yao, B.Y., Chen, Y.I., Liu, Y.H., Fang, Z.S., Chen, J.Y., Chen, W.Y., Lee, N.N., Chen, H.W., and Hu, C.M.J.* 2019. Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions. Nat Commun 10(1):1057. (IF=16.6; 6/73; Q1)
  4. Lin, L.C., Chattopadhyay, S, Lin J.C., and Hu, C.M.J.* 2018. Advances and opportunities in nanoparticle- and nanomaterial-based vaccines against bacterial infections. Adv Healthc Mater 7(13):e1701395. (IF=10; 8/96; Q1)
  5. Ka, S.M., Chao, L. K., Lin, J.C., Chen, S.T., Li, W.T., Lin, C.N., Cheng, J.C., Jheng, H.L., Chen A., and Hua, K.F.*2016. A low toxicity synthetic cinnamaldehyde derivative ameliorates renal inflammation in mice by inhibiting NLRP3 inflammasome and its related signaling pathways. Free Radic Biol Med 91:10-24. (IF=7.4 ;43/285; Q1)
  6. Chen, H.W., Huang, C.Y., Lin, S.Y., Fang, Z.S., Hsu, C.H., Lin, J.C., Chen, Y.I., Yao, B.Y., and Hu, C.M.J.*2016.Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection. Biomaterials 106:111-8. (IF=14; 4/96; Q1)
  7. Ka, S.M., Lin, J.C., Lin, T.J., Liu, F.C., Chao, L.K., Ho, C.L., Yeh, L.T., Sytwu ,H.K., Hua, K.F., Chen, A.* 2015. Citral alleviates an accelerated and severe lupus nephritis model by inhibiting the activation signal of NLRP3 inflammasome and enhancing Nrf2 activation. Arthritis Res Ther 17:331. (IF=4.9; 12/34; Q2)
  8. Lin, J.C., Lin, S.C., Chen, W.Y., Yen, Y.T., Lai, C.W., Tao, M.H., Lin, Y.L., Miaw. S.C., and Wu-Hsieh, B.A.*2014.Dengue viral protease interaction with NF-kappaB inhibitor alpha/beta results in endothelial cell apoptosis and hemorrhage development. J Immunol 193:1258-67. (IF=4.4; 77/161; Q2)
  9. Chang, L.Y., Lin, J.C., Chang, C.W., Ho, W.H., Chen, Y.T., Peng, J.L., and Hung, S.L.* 2009. Inhibitory effects of safrole on phagocytosis, intracellular reactive oxygen species, and the activity of myeloperoxidase released by human polymorphonuclear leukocytes. J Periodontol 80:1330-7. (IF=4.3; 12/91; Q1)
  10. Chen, D.C., Lee, Y.Y., Yeh, P.Y., Lin, J.C., Chen, Y.L., and Hung, S.L.* 2008. Eugenol inhibited the antimicrobial functions of neutrophils. J Endod 34:176-80. (IF=4.2; 14/91; Q1)
  11. Lai, Y.L., Lin, J.C., Yang,S.F., Liu, T.Y., and Hung, S.L.* 2007. Areca nut extracts reduce the intracellular reactive oxygen species and release of myeloperoxidase by human polymorphonuclear leukocytes. J Periodontal Res 42:69-76. (IF=3.5; 26/91; Q2)
  12. Shui, H.A., Ka, S.M., Lin, J.C., Lee, J.H., Jin, J.S., Lin ,Y.F., Sheu, L.F., and Chen, A.* 2006. Fibronectin in blood invokes the development of focal segmental glomerulosclerosis in mouse model. Nephrol Dial Transplant 21:1794-802. (IF=6.1; 4/26; Q1)


技術轉移

Artificial antigen presenting cell system and uses thereof (Celtec Inc.)   2020/08/21
 
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