林宥成

  • 發布日期：115-06-05
  • 更新日期：115-06-29
  • 發布單位：牙醫學院
林宥成老師
 
林宥成 (Yu-Cheng LIN) 副教授

電子郵件：ylin@nycu.edu.tw

聯絡電話：02-2826-7130

辦公室位置：牙醫館 211 研究室

專長：生物資訊、機器學習、基因體學、微生物學、遺傳學

簡介：
  • 本實驗室遊走於機器學習、基因體、與口腔醫學的交界，但基本上我們每天做的就是把咖啡轉換成程式碼 😃。
  • 我們相信生物學的本質是「小」的科學，因此我們採行軟體設計的敏捷開發，整合「乾、濕」實驗，挖掘生物新知。
     
學歷：
  • 2018：美國哥倫比亞大學　生物學系　                      博士
  • 2010：國立台灣大學　       微生物與生化學研究所　碩士
  • 2008：國立台灣大學　       牙醫學系　                      學士
經歷：
  • 2021 – 迄今：國立陽明交通大學副教授
  • 2019 – 2021：美國LifeMine Therapeutic　資料科學部門計算   生物學研究員
  • 2018 – 2019：美國New England Biolabs　研究部門　              博士後研究員

研究方向：口腔癌基因體學、口腔微生物菌相、AI疾病模型
 


近五年代表著作：
 
  1. Yang C-C, Washio J, Lin Y-C, Hsu M-L, Wang D-H, Tsai F-T, Lin Y-M, Tu H-F, Chang H-C & Takahashi N (2025) Microbiome Signatures and Dysbiotic Patterns in Oral Cancer and Precancerous Lesions. Oral Diseases, https://doi.org/10.1111/odi.15317.
  2. Florek LC, Lin X, Lin Y-C, Lin M-H, Chakraborty A, Price-Whelan A, Tong L, Rahme L & Dietrich LEP (2024) The L-lactate dehydrogenases of Pseudomonas aeruginosa are conditionally regulated but both contribute to survival during macrophage infection. mBio, https://doi.org/10.1128/mbio.00852-24.
  3. Chang H-C, Yang C-C, Loi L-K, Hung C-H, Wu C-H & Lin Y-C (2024) Interplay of p62-mTORC1 and EGFR Signaling Promotes Cisplatin Resistance in Oral Cancer. Heliyon, https://doi.org/10.1016/j.heliyon.2024.e28406.
  4. Tsai F-T, Yang C-C, Lin Y-C, Hsu M-L, Hong G, Yang M-C, Wang D-H, Huang L-J, Lin C-T, Hsu W-E & Tu H-F (2024) Temporal stability of tongue microbiota in older patients – A pilot study. Journal of Dental Sciences, https://doi.org/10.1016/j.jds.2024.01.012.
  5. *Loi L-K, *Yang C-C, Lin Y-C, Su Y-F, Juan Y-C, Chen Y-H & Chang H-C (2023) Decoy peptides effectively inhibit the binding of SARS-CoV-2 to ACE2 on oral epithelial cells. Heliyon, 9(12): e22614. *These authors contributed equally.
  6. Huang P-C, Chang C-W, Lin Y-C, Chen C-Y, Chen T-Y, Chuang L-T, Liu C-J, Huang C-L & Li W-C (2023) Pyruvate Kinase Differentially Alters Metabolic Signatures during Head and Neck Carcinogenesis. International Journal of Molecular Sciences, 24(23): 16639.
  7. Chansaenroj A, Kornsuthisopon C, Suwittayarak R, Rochanavibhata S, Loi L-K, Lin Y-C & Osathanon T (2023) IWP-2 modulates the immunomodulatory properties of human dental pulp stem cells in vitro. International Endodontic Journal, 2023;00:1–18.
  8. Wang D-H, Tsai F-T, Tu H-F, Yang C-C, Hsu M-L, Huang L-J, Lin C-T, Hsu W-E & Lin Y-C (2023) Profiles of oral microbiome associated with nasogastric tube feeding. Journal of Oral Microbiology, doi.org/10.1080/20002297.2023.2200898.
  9. Chang S-R, Chou C-H, Liu C-J, Lin Y-C, Tu H-F, Chang K-W & Lin S-C (2023) The Concordant Disruption of B7/CD28 Immune Regulators Predicts the Prognosis of Oral Carcinomas. International Journal of Molecular Sciences, 2023 Mar 21;24(6):5931.
  10. Tsai F-T, Wang D-H, Yang C-C, Lin Y-C, Huang L-J, Tsai W-Y, Li C-W, Hsu W-E, Tu H-F & Hsu M-L (2022) Locational effects on oral microbiota among long-term care patients. Journal of Oral Microbiology, 14(1): 2033003.
  11. *Yang W, *Lin Y-C, Johnson W, Dai N, Vaisvila R, Weigele PR, Lee Y-J, Corrêa IR Jr, Schildkraut I & Ettwiller L (2021) A Genome-Phenome Association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA. eLife, 10:e70021. *These authors contributed equally.
  12. Lee Y-J, Dai N, Muller SI, Guan C, Parker MJ, Fraser ME, Walsh SE, Sridar J, Mulholland A, Nayak K, Sun Z, Lin Y-C, Comb DG, Marks K, Gonzalez R, Dowling DP, Bandarian V, Saleh L, Corrêa IR Jr & Weigele PR (2021) Pathways of thymidine hypermodification. Nucleic Acids Research, 50(6), 3001–3017.
  13. Baum C, Lin Y-C, Fomenkov A, Anton BP, Chen L, Yan B, Evans TC, Roberts RJ, Tolonen AC, Ettwiller L (2021) Rapid identification of methylase specificity (RIMS-seq) jointly identifies methylated motifs and generates shotgun sequencing of bacterial genomes. Nucleic Acids Research, gkab705.
  14. Wang B, Lin Y-C, Vasquez-Rifo A, Jo J, Price-Whelan A, McDonald ST, Brown LM, Sieben C, Dietrich LEP (2021) Pseudomonas aeruginosa PA14 produces R-bodies, extendable protein polymers with roles in host colonization and virulence. Nature Communications, 12(1): 4613.
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