陳虹如 助理教授

專任助理教授
陳虹如
Hong-Ru Chenoid
phone 02-2826-7000／lab: ext. 67099
mail hrchen@nycu.edu.tw
address 生物醫學大樓7樓R709
lab 實驗室網頁
08/2022–present 國立陽明交通大學 生命科學系暨基因體科學研究所 助理教授
02/2021–07/2022 University of Virginia School of Medicine Department of Neuroscience Assistant Professor
01/2018–01/2021 University of Virginia School of Medicine Department of Neuroscience Research Associate
12/2015–12/2017 Emory University School of Medicine Department of Pediatrics Postdoctoral Research Fellow
08/2015–11/2015 National Yang-Ming University Brain Research Center Postdoctoral Research Fellow
  • Ph.D.Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan
  • Trainee. Embryology Course, Marine Biological Laboratory, MA, USA
  • M.S.Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
  • B.S.Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
Neuroimmunology, Neonatal Brain Injury, Stroke, Autism, and Tauopathy
  • 專題討論
  • 生涯發展與學習
Our primary research interest is to investigate how neurons and monocyte-derived pathological microglia interact to mediate neural physiology and behavior in various neurological conditions, towards the development of immune-targeted therapies of the disease condition. The diseases that we study include maternal immune activation, neonatal hypoxia-ischemia (HI), infection-sensitized HI, and neonatal stroke. To test this idea, we have developed a two-hit model of neurodevelopmental defects by subjecting the offspring of murine maternal immune activation (MIA) under a moderate Rice-Vannucci HI insult to produce autistic-like behaviors and synaptic defects.
hong
Our second research interest is to explore the disease model of neuropil clumps caused by phosphorylated tau protein, and how monocytes are involved in the regulation of myelin damage and to develop the new therapeutic methods in neurodegenerative diseases (such as Alzheimer's disease and tauopathy).
hong
期刊發表
  1. Hsiang-Ying Lin and Hong-Ru Chen# (2025) The Double-Edged Sword of Monocytes in Alzheimer’s Disease: From Clinical Observations to Preclinical Models. Journal of Biomedical and Laboratory Sciences. Vol. 37, No. 3 (#corresponding author)
  2. Hong-Ru Chen, Hsiao-Tien Hagar, Kuan-Wei Wang, Stacy Hovde, Hsiang-Ying Lin, Min-Hsuan Lin, Cheng-Chun Chang, Ching-Yung Wang, Chia-Yen Chen, Emily Bian, Marchelle R Smucker, Min-Hao Kuo, Chia-Yi Kuan (2025) Intrahippocampal delivery of hyperphosphorylated human tau oligomers induces neurodegeneration in non-transgenic wildtype mice. 
  3. Zhongxiao Fu, Mallikarjunarao Ganesana, Philip Hwang, Xiao Tan, Melissa Marie Kinkaid, Yu-Yo Sun, Emily Bian, Aden Weybright, Hong-Ru Chen, Katia Sol-Church, Ukpong B. Eyo, Clare Pridans, Francisco J. Quintana, Simon C. Robson, Pankaj Kumar, B. Jill Venton, Anne Schaefer, Chia Yi Kuan (2025) Microglia modulate cerebral blood flow and neurovascular coupling through ectonucleotidase CD39. Nature communications, 16:956
  4. Naidi Sun*, Yu-Yo Sun*, Rui Cao, Hong-Ru Chen, Yiming Wang, Elizabeth Fugate, Marchelle R. Smucker, Yi-Min Kuo, P. Ellen Grant, Diana M. Lindquist, Chia-Yi Kuan, Song Hu (2024) Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia. (*co-first author)
  5. Zhenfeng Song*, Kuang-Wei Wang*, Hsiao-Tien Chien Hagar*, Hong-Ru Chen, Chia-Yi Kuan, Kezhong Zhang, and Min-Hao Kuo (2023) P-tau Inflicts Intracellular Stress Responses That Are Mitigated by Apomorphine. Molecular Neurobiology, DOI: 10.1007/s12035-023-03689-x (*co-first author)
  6. Hong-Ru Chen, Ton DeGrauw, Chia-Yi Kuan (2023) (Phospho) creatine: The Reserve and Merry-Go-Round of Brain Energetics. Neural Regeneration Research, 18 (2) 327-328
  7. Yu-Yo Sun, Hui-Wen Yao, Hong-Ru Chen, Ching-Wen Chen, Melissa M Kinkaid, Chia-Yi Kuan (2022) Stroke Propensity in a Mouse Model of b-Thalassemia Intermedia. Neurobiology of Disease, 171, 105802
  8. Hong-Ru Chen, Ching-Wen Chen, Yi-Min Kuo, Brandon Chen, Irena S. Kuan, Henry Huang, Jolly Lee, Neil Anthony, Chia-Yi Kuan, Yu-Yo Sun (2022) Monocytes promote acute neuroinflammation and become pathological microglia in neonatal hypoxic-ischemic brain injury. Theranostics, https://www.thno.org/v12p0512.htm
  9. Kanchan Bisht, Kenneth A. Okojie, Kaushik Sharma, Dennis H. Lentferink, Yu-Yo Sun, Hong-Ru Chen, Joseph O. Uweru, Saipranusha Amancherla, Zainab Calcuttawala, Antony Brayan Campos Salazar, Bruce Corliss, Lara Jabbour, Jordan Benderoth, Bria Friestad, William A. Mills III, Brant Isakson, Marie-Ève Tremblay, Chia-Yi Kuan, Ukpong B. Eyo (2021) Capillary-associated microglia regulate vascular structure and function. Nature communications, https://doi.org/10.1038/s41467-021-25590-8
  10. Hong-Ru Chen, Xiaohui Zhang-Brotzge, Yury M Morozov, Yuancheng Li, Siming Wang, Helen Zhang, Irena S Kuan, Elizabeth M Fugate, Hui Mao, Yu-Yo Sun, Pasko Rakic, Diana M Lindquist, Ton DeGrauw, Chia-Yi Kuan (2021) Creatine transporter deficiency impairs stress-adaptation and brain energetics homeostasis. JCI Insight, https://doi.org/10.1172/jci.insight.140173
  11. Hong-Ru Chen, Ching-Wen Chen, Nandita Mandhani, Jonah C Short-Miller, Marchelle R Smucker, Yu-Yo Sun, Chia-Yi Kuan (2020) Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model of Neurodevelopmental Defects. Journal of Neuroscience, 40 (49) 9386-9400
  12. Chia-Yi Kuan, Hong-Ru Chen, Ning Gao, Yi-Min Kuo, Ching-Wen Chen, Dianer Yang, Melissa M Kinkaid, Erding Hu, Yu-Yo Sun (2020) Brain targeted hypoxia-inducible factor stabilization reduces neonatal hypoxic ischemic brain injury. Neurobiology of Disease, 148:105200
  13. Hong-Ru Chen, Yu-Yo Sun, Ching-Wen Chen, Yi-Min Kuo, Irena S Kuan, Zheng-Rong Tiger Li, Jonah C Short-Miller, Marchelle R Smucker, Chia-Yi Kuan (2020) Fate mapping via CCR2-CreER mice reveals monocyte-to microglia transition in development and neonatal stroke. Science Advances, DOI:10.1126/sciadv.abb2119
  14. Yu-Yo Sun*, Yi-Min Kuo*, Hong-Ru Chen, Jonah C Short-Miller, Marchelle R Smucker, Chia-Yi Kuan (2020, Apr) A murine photothrombotic stroke model with an increased fibrin content and improved responses to tPA-lytic treatment. Blood Advances, 4(7): 1222–1231 (*co-first author)
  15. Hong-Ru Chen, Hsien-Chia Juan, Yu-Hui Wong, Jin-Wu Tsai, Ming-Ji Fann (2017) Cdk12 Regulates Neurogenesis and Late-Arising Neuronal Migration in the Developing Cerebral Cortex. Cerebral Cortex, 27(3): 2289–2302
  16. Hsien-Chia Juan, Yong Lin, Hong-Ru Chen, Ming-Ji Fann (2016) Cdk12 is essential for embryonic development and the maintenance of genomic stability. Cell Death and Differentiation, 23, 1038–1048
  17. Hong-Ru Chen, Guan-Ting Lin, Chun-Kai Huang, Ming-Ji Fann (2014) Cdk12 and Cdk13 regulate axonal elongation through a common signaling pathway that modulates Cdk5 expression. Experimental Neurology, 261: 10-21
  18. Hong-Ru Chen, Hung-Chi Yang, Dennis Jine-Yuan Hsieh, Zijuan Liu, Kan-Jen Tsai (2011) Zebrafish sod1 and sp1 expression are modulated by the copper ATPase gene atp7a in response to intracellular copper status. Chemico-Biological Interactions, 189 (3) 192-197
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