廖淑惠 教授

退休教授
廖淑惠
Liaw, Shwu-Huey
 
  • 2003-2018 國立陽明大學 生命科學系暨基因體科學研究所 教授
  • 國立陽明大學 生命科學系暨基因體科學研究所 副教授
  • 國立臺灣大學 分子醫學所 副教授
  • 加州大學洛杉磯分校 分子生物所 博士後研究
  • 美國加州大學洛杉磯分校 生化所 博士
  • 國立臺灣大學 化學系 學士
結構生物學、結構生物資訊、生物化學
  • 生命科學（二上）：生物化學
  • 生命科學實驗（二上）
  • 分析生化學
  • 結構生物學（一）
  • 細胞骨架力學
  • 生命科學技術
  • 專題討論（碩）
  1. Wei, C. L., Yang, Y. B., Liu, W. C., Chen, W. Y., Liaw, S. H.*, and Ysai, Y. C.* Mutational Shuffling of Streptomyces clavuligerus Deacetoxycephalosporin C Synthase to Improve Penicillin G Expansion. In submission.
  2. Chen, S. C., Shen, C. Y., Yen, T. M., Yu, H. C., Chang, T. H., Lai, W. L., and Liaw, S. H.* Evolution of vitamin B2 biosynthesis: eubacterial RibG and fungal Rib2 deaminases. Acta Cryst. D In press
  3. Huang, Y. L., Chung, T. W., Chen, C. H, Chang, C. M., Liao, C. C., Tsay, Y. G., Shaw, G. C., Liaw, S. H., Sun, C. M., and Lin, C. H.* Qualitative analysis of the fluorophosphonate-based chemical probes using the serine hydrolases from mouse liver and poly-3-hydroxybutyrate depolymerase (PhaZ) from Bacillus thuringiensis Anal. Bioanal. Chem. In press
  4. Huang, T. H., Peng, H. J., Su, S. N., and Liaw, S. H.* (2012) Various cross-reactivity of the grass pollen group 4 allergens: crystallographic study of the Bermuda grass isoallergen Cyn d 4. Acta Cryst. D68, 1303-1310
  5. Chen, C. S., Chiou, C. T., Chen, G., Chen, S. C., Hu, C. Y., Chi, W. K., Chu, Y. D., Hwang, L. H., Chen, P. J., Liaw, S. H.*, Chen, D. S.*, and Chern, J. W.* (2009) Structure-based discovery of triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. J. Med. Chem. 52, 2716-2723
  6. Chen, S. C., Lin, Y. H, Yu, H. C., and Liaw, S. H.* (2009) Complex structure of Bacillus subtilis RibG: the reduction mechanism during riboflavin biosynthesis. J. Biol. Chem. 284, 1725-1731
  7. Huang, C. H., Winkler, A., Chen, C. L., Lai, W. L., Tsai, Y. C., Macheroux, P., and Liaw, S. H.* (2008) Functional roles of the 6-S-cysteinyl, 8-N1-histidyl FAD in glucooligosaccharide oxidase from Acremonium strictum. J. Biol. Chem. 283, 30990-30996
  8. Chen, S. C., Chang, Y. C, Lin, C. H, Lin, C. H., and Liaw, S. H.* (2006) Crystal structure of Bacillus subtilis RibG: The ring structure of the deaminase-reductase in the riboflavin biosynthesis. J. Biol. Chem. 281, 7605-7613
  9. Huang, C. H., Lai, W. L., Lee, M. H., Chen, C. J., Vasella, A., Tsai, Y. C., and Liaw, S. H.* (2005) Crystal structure of glucooligosaccharide oxidase from Acremonium strictum: A novel flavinylation of 6-S-cysteinyl, 8a-N1-histidyl FAD. J. Biol. Chem. 280, 38831-38838.
  10. Lai, W. L., Lee, M. H., Liaw, S. H.*, and Tsai, Y. C. (2005) Structural characterization of glucooligosaccharide oxidase from Acremonium strictum. Appl. Environ. Microbiol. 71, 8881-8887.
  11. Wei, C. L.,Yang, Y. B., Deng, C. H., Liu, W. C., Hsu, J. S., Lin, Y. C., Liaw, S. H.*, and Tsai, Y. C.* (2005) Directed evolution of Streptomyces clavuligerus deacetoxycephalosporin c synthase for enhancement of penicillin G expansion. Appl. Environ. Microbiol. 71, 8873-8870.
  12. Tsai, M. L., Liaw, S. H.*, and Chang, N. C.* (2004) The high-resolution crystal structure of Ym1 suggests a lack of N-acetylglucosamine-binding affinity. J. Struct. Biol. 148, 290-296.
  13. Hsu, J. S., Yang, Y. B., Deng, C. H., Wei, C. L., Liaw, S. H.*, and Tsai, Y. C.* (2004) Family shuffling of expandase genes to enhance substrate specificty to penicillin G. Appl. Environ. Microbiol. 70, 6257-6263.
  14. Liaw, S. H.*, Chang, Y. J., Lai, C. T., Chang, H. C., and Chang, G. G. (2004) Crystal structure of the Bacillus subtilis guanine deaminase. The first domain-swapped structure in the cytidine deaminase superfamily. J. Biol. Chem. 279, 35479-35485.
  15. Lai, W. L., Chou, L. Y., Ting, C. Y., Kirby, R., Tsai, Y. C., Wang, A. H. J., and Liaw, S. H.* (2004) The functional role of the binuclear metal center in D-aminoacylase. One-metal activation and second-metal inhibition. J. Biol. Chem. 279, 13962-13967.
  16. Ko, T.P., Lin, J. J., Hu, C. Y., Hsu, Y. H., Wang, A. H. J., and Liaw, S. H.* (2003) Crystal structure of the yeast cytosine deaminase. Insights into the enzyme mechanism and evolution. J. Biol. Chem. 278, 19111-19117.
  17. Liaw, S. H., Chen, S. J., Ko, T. P., Hsu, C. S., Chen, C. J., Wang, A. H. J.*, and Tsai, Y. C.* (2003) Crystal Structure of D-aminoacylase from Alcaligenes faecalis DA1. A Novel subset of amidohydrolases and insights into the enzyme mechanism. J. Biol. Chem. 278, 4957-4962.
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