{"subject":"陳俊銘 教授","pubUnitName":null,"posterDate":null,"updateDate":null,"detailContent":"
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專任教授兼所長及系主任
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\"陳俊銘\"
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Chun-Ming Chen\"oid\"
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\"phone\" 02-2826-7339／lab: ext.65721 or 65785
\r\n\"mail\" cmchen@nycu.edu.tw
\r\n\"address\" 傳統醫學大樓甲棟1樓R110
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  • 2005 吳大猷先生紀念獎
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  • 2003 The Connie and Jim Walter Fellowship in Sarcoma
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  • 2001 M.D. Anderson Cancer Center, Prostate Cancer Research Program Award
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  • 2021-present 兼任國立陽明交通大學 生命科學系暨基因體科學研究所 所長
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  • 2011-2019 兼任國立陽明大學實驗動物中心主任
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  • 2016-present 國立陽明交通大學 生命科學系暨基因體科學研究所 教授
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  • 2008-2016 國立陽明大學 生命科學系暨基因體科學研究所 副教授
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  • 2004-2008 國立陽明大學 生命科學系暨基因體科學研究所 助理教授
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  • 2000-2004 Department of Molecular Genetics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA 博士後研究員
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  • 1998-2000 國軍桃園總醫院病理部 義務役少尉
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June 1998 國立陽明大學 生化所 博士
\r\nJune 1993 國立陽明大學 生化所 碩士
\r\nJune 1991 中山醫學院 營養系 學士
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發育生物學、癌症基因學
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  • 生命科學（二下）
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  • 分子生物學
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  • 癌症生物學
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  • 小鼠遺傳﹑發育與表現型分析
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  • 生物學
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  • 以轉殖基因小鼠與人類癌症類器官培養模式探討上皮癌症的形成與惡化
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我們以轉殖基因小鼠為模式，利用特定組織專一性的基因剔除或表現系統，廣泛地在單層柱狀上皮細胞或是複層上皮的基底細胞，誘導多個抑癌基因(如Pten，p53,DPH1/Ovca1等)缺失，同時誘導報導基因(如綠螢光蛋白基因)的表現，讓我們能夠在不同器官的柱狀上皮或基底上皮剔除抑癌基因時，進行研究並追蹤癌症細胞的起始與進展的機制。此外，器官專一性的基因剔除系統也讓我們能更專一地探討特定的癌症成因。我們目前對於肝癌與攝護腺癌的疾病動物模式有成熟的分析平台，而對於胰臟癌與卵巢癌的起源細胞及其惡化機制，亦正在積極探討中。另一方面，建立臨床癌症手術檢體的類器官培養(patient-derived organoid culture)，作為研究高度複雜的上皮癌之活體外三維培養平台，藉以了解源自不同病人的癌症類器官之共通性與歧異性，以及對化療藥物或標靶藥物之反應。希望在未來能藉此而發展更好的治療策略來對抗癌症，並對癌症精準醫療提供新的想法。
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  • 目前實驗室的研究方向與計畫分列如下:
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研究方向與計畫 Current Research Projects
\r\n1. 利用類器官培養與轉殖基因小鼠模式探索OVCA1/DPH1在乳癌與卵巢癌扮演的角色 Deciphering the roles of OVCA1/DPH1 in breast and ovarian cancers using organoid cultures and genetically-modified mice (國科會 計畫109-2320-B-010-014-MY3)
\r\n2. 探討真核生物第二轉譯延伸因子的白喉醯胺修飾對肝細胞癌化的影響The Impacts of Diphthamide Modification of Eukaryotic Elongation Factor 2 (eEF2) in Hepatocellular Carcinogenesis (國衛院計畫NHRI-EX111-11122BI)
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* corresponding author
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  1. Tu, W-L, Chih, Y-C, Shih, Y-T, Yu, Y-R, You, L-R, and Chen, C-M* Context-specific roles of diphthamide deficiency in hepatocellular carcinogenesis. J Pathol. 2022; 258: 149-163.
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  2. Chan, C-H, Chen, C-M., Wu Lee, Y-H, and You, L-R.* DNA Damage, Liver Injury, and Tumorigenesis: Consequences of DDX3X Loss. Mol Cancer Res, 2019; 17: 555-566.
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  3. Tu, W-L, You, L-R, Tsou, A-P, and Chen, C-M*. Pten haplo-deficiency accelerates liver tumor growth in microRNA122a-null mice via expansion of periportal hepatocyte-like cells. Am J Pathol 2018; 188: 2688-2702.
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  4. Hsu W-H, Chen C-M, You L-R*. COUP-TFII is required for morphogenesis of the neural crest-derived tympanic ring. Sci Rep. 2017, 7: 12386.
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  5. Wang C-Y, Tang M-C, Chang W-C, Furushima K, Jang C-W, Behringer RR, Chen C-M*. PiggyBac Transposon-Mediated Mutagenesis in Rats Reveals a Crucial Role of Bbx in Growth and Male Fertility. Biol Reprod. 2016; 95: 51, 1-9.
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  6. Li H-K, Mai R-T, Huang H-D, Chou C-H, Chang Y-A, Chang Y-W, You L-R, Chen C-M, Wu Lee Y-H*. DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma. Sci Rep. 2016;6:28637.
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  7. Chen C-Y, Chan C-H, Chen C-M, Tsai Y-S, Tsai T-Y, Wu Lee Y-H, You L-R*. Targeted Inactivation of Murine Ddx3x: Essential Roles of Ddx3x in Placentation and Embryogenesis. Hum Mol Genet. 2016; 25: 2905-2922.
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  8. Lu T-L and Chen C-M*. ß-Catenin in epithelial tumorigenesis. Aging 2015; 7: 467-468.
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  9. Liang C-C, Lu T-L, Yu Y-R, You L-R and Chen C-M*. ß-Catenin activation drives thymoma initiation and progression in mice. Oncotarget 2015; 6:13978-13993.
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  10. Lu T-L and Chen C-M* .Differential Requirements for ß-Catenin in Murine Prostate Cancer Originating from Basal versus Luminal Cells. J Pathol. 2015; 236: 290-301.
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  11. Yu Y-R, You L-R, Yan Y-T and Chen C-M*. Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker Syndrome. Hum Mol Genet, 2014; 23:5579-5596.
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  12. Liang C-C, You L-R, Yen J-J, Liao N-S, Yang-Yen H-F, Chen C-M*. Thymic epithelial beta-catenin is required for adult thymic homeostasis and function. Immunol Cell Biol 2013; 91: 511-23.
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  13. Lu T-L, Huang Y-F, You L-R, Chao N-C, Su F-Y, Chang J-L and Chen C-M*. Conditionally Ablated Pten in Prostate Basal Cells Promotes Basal-to-Luminal Differentiation and Causes Invasive Prostate Cancer in Mice. Am J Pathol 2013; 182: 975-991.
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  14. Cheng T-L, Wu Y-T, Lai C-H, Kao Y-C, Kuo C-H, Liu S-L , Hsu Y-Y, Chen P-K, Cho C-F, Wang K-C, Lin W-L, Chang B-I, Chen C-M, Weiler H, Shi GY, Wu HL* Thrombomodulin Regulates Keratinocyte Differentiation and Promotes Wound Healing. J Invest Dermatol 2013; 133:1638-1645.
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  15. Hsu W-H, Yu Y-R, Hsu S-H, Yu W-C, Chu Y-H, Chen,Y-J, Chen C-M and You L-R* The Wilms’ tumor suppressor Wt1 regulates Coronin 1B expression in the epicardium. Exp Cell Res 2013; 319: 1365-1381.
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  16. Chiang M-F, Yang S-Y, Lin I-Y, Hong J-B, Lin S-J, Ying H-Y, Chen C-M, Wu S-Y, Liu F-T, Lin K-I*. Inducible deletion of the Blimp-1 gene in adult epidermis causes granulocyte-dominated chronic skin inflammation in mice. Proc Natl Acad Sci USA 2013; 110: 6476-6481.
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