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National Yang Ming Chiao Tung University

NYCU ELITE

  • Publish Date:2026-06-29
NYCU’s iGEM Team Wins Gold, Adding New Momentum to Global Evolution
Professor Wen-Liang Chen advocates for a shift toward objective-driven research, where genes are treated as modular “building blocks” to solve complex biological challenges © NYCU Elite
Professor Wen-Liang Chen advocates a shift toward objective-driven research, in which genes are treated as modular “building blocks” to solve complex biological challenges.
 
By NYCU ELITE
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The international Genetically Engineered Machine (iGEM) Competition is the world’s largest-scale student competition in synthetic biology, attracting approximately 300 teams to participate each year. In the 2025 competition, National Yang Ming Chiao Tung University (NYCU) won the gold medal with its “Genomic Integrated Bio-Brick Platform (GenOMe)” and was nominated for two special awards. GenOMe employs a standardized, modular design like LEGO bricks, supplemented by precise mathematical modeling for prediction, which dramatically increased the success rate of genome integration technology from 0.2% to 80%

This means that the time required for culturing and screening microbial strains, which previously could last for six months to a year, will be reduced to a few weeks or even a few days in the future. This development demonstrates tremendous value for both commercial and clinical applications and has earned high praise from international reviewers.

Wen-Liang Chen, the Professor of the Department of Biological Science and Technology at NYCU, who has served as the iGEM team leader since 2013, pointed out that the Massachusetts Institute of Technology (MIT) founded iGEM with the aim of applying an engineering mindset to solve problems faced in biological research. The hope is that, by modularizing genes as building blocks, they can be arranged and combined according to research objectives to create “biological machines” with specific functions capable of performing specialized tasks. NVIDIA founder Jensen Huang also publicly stated that biology will evolve from the “science of discovery” toward the “science of engineering” in the future.

“While there is a certain element of romance and artistry to discovery, engineering must have clear objectives,” Prof. Chen emphasized. He noted that during the iGEM competition participation and training program, NYCU instructors did not proactively provide answers; instead, they allowed students to take the lead to a large extent in defining problems, seeking resources, and solving issues.

For example, the team had originally planned to refine GenOMe and develop new applications as their entry for the 2026 competition, but if students decided at the last minute to change the topic, Prof. Chen respected their decision: “Even if there wasn’t enough time, students must take responsibility. Regret is sometimes an indispensable part of education.”

Solving Biological Problems with an Engineering Mindset

Wen-Liang Chen, the Professor of the Department of Biological Science and Technology at NYCU, who has served as the iGEM team leader since 2013, pointed out that the Massachusetts Institute of Technology (MIT) founded iGEM with the aim of applying an engineering mindset to solve problems faced in biological research. The hope is that, by modularizing genes as building blocks, they can be arranged and combined according to research objectives to create “biological machines” with specific functions capable of performing specialized tasks. NVIDIA founder Jensen Huang also publicly stated that biology will evolve from the “science of discovery” toward the “science of engineering” in the future.

“While there is a certain element of romance and artistry to discovery, engineering must have clear objectives,” Prof. Chen emphasized. He noted that during the iGEM competition participation and training program, NYCU instructors did not proactively provide answers; instead, they allowed students to take the lead to a large extent in defining problems, seeking resources, and solving issues.

For example, the team had originally planned to refine GenOMe and develop new applications as their entry for the 2026 competition, but if students decided at the last minute to change the topic, Prof. Chen respected their decision: “Even if there wasn’t enough time, students must take responsibility. Regret is sometimes an indispensable part of education.”
 
Highlighting the team’s diverse culture, Professor Chen notes how students from the humanities have even led the team to merge “BioArt” with synthetic biology, completely redefining traditional research boundaries © NYCU Elite
Highlighting the team’s diverse culture, Professor Chen notes how students from the humanities have even led the team to merge “BioArt” with synthetic biology, completely redefining traditional research boundaries © NYCU Elite

The members of NYCU’s iGEM team come from diverse backgrounds. The team in 2025 consists of 18 freshmen students from the Department of Biological Science and Technology, the Department of Electronics and Electrical Engineering, the School of Medicine, the Department of Biotechnology and Laboratory Science in Medicine, and the Department of Computer Science. “The most challenging part was mathematical modeling, which could not be accomplished by students with a computer science background alone. The equations for GenOMe were developed collaboratively by members from the Department of Biological Science and Technology, the School of Medicine, and the Department of Computer Science,” said Prof. Chen.

In this type of Project-Based Learning (PBL) training, if students discover that they lack skills in areas such as experimental methods or mathematical modeling during the problem-solving process, they must take the initiative to learn and fill in the gaps in their fundamental science knowledge. Prof. Chen added, “AI generates content at an astonishing rate. In this era of rapidly expanding knowledge and rapid AI development, it is more important for students to learn to set goals so that they can efficiently filter out the content they truly need!”

From cold-calling experts to pitching research like a startup product, NYCU students cultivate essential professional skills—initiative, resilience, and bilingual communication—equipping them to transform academic ideas into tangible social contributions​ © NYCU EliteFrom cold-calling experts to pitching research like a startup product, NYCU students cultivate essential professional skills—initiative, resilience, and bilingual communication—equipping them to transform academic ideas into tangible social contributions​.
 
 
It is particularly worth noting that in 2023, the team was even led by a student from the College of Humanities, Arts, and Social Sciences. The team introduced the concept of “BioArt,” using engineered bacteria combined with the three primary RGB colors to create various patterns, and even organized an online art exhibition and expert lectures. “By combining soft elements into the rigid concepts of engineering and biology, the team completely overturned conventional notions of what biology and engineering can be!” Prof. Chen said with a grin.

Proactive Seeds Eventually Blossom and Bear Fruit

In addition, Prof. Chen observed that iGEM places great emphasis on the “Integrating Human Practices” aspect of its competition design, which is highly inspiring for education. “The concept of this competition design is to have teams demonstrate whether their technology makes a tangible contribution to society and industry.” He further explained that if participants treat their entry as a startup product, students must engage with other researchers and industry professionals during the R&D phase. This not only helps them understand the genuine needs of these stakeholders and adjust their R&D direction accordingly, but also enables them to gain recognition for their research concepts and value.

“We’ve had students ride their scooters all the way from Hsinchu to the Taiwan Agricultural Research Institute, Ministry of Agriculture, in Taichung, to discuss the accuracy of predictive models with researchers. Some students had personally written letters inviting the director of the Academia Sinica to grant an interview. Students reached out not only to research institutions but even to businesses on their own initiative.” Prof. Chen recalled that if the content of a student’s invitation letter was insufficient, the process of securing an interview was bound to encounter setbacks. It was only then that instructors stepped in to guide students in refining their interview invitation process. “As long as we can plant the seed of initiative in students’ minds, the energy they bring to society one day will be truly remarkable.”

Before officially announcing the entry, he will help students continuously improve their spoken English skills, with the goal of being able to explain the key features of the entry in 3 to 5 minutes. “At the iGEM exhibition, students couldn’t just sit there waiting for people to come to them. I also told the students they must take the initiative to invite students from other universities or judges to visit the NYCU booth.” Prof. Chen’s strict demands on the iGEM team members finally bore beautiful fruit when the students used their award-winning theme to launch a startup.
Taking Bold Steps and Exploring Endless Possibilities

From cold-calling experts to pitching research like a startup product, NYCU students cultivate essential professional skills—initiative, resilience, and bilingual communication—equipping them to transform academic ideas into tangible social contributions​ © NYCU Elite
From cold-calling experts to pitching research like a startup product, NYCU students cultivate essential professional skills—initiative, resilience, and bilingual communication—equipping them to transform academic ideas into tangible social contributions​.

Taking Bold Steps and Exploring Endless Possibilities

Since 2014, Prof. Chen’s team has won numerous iGEM grand awards and gained recognition over several consecutive years with their “Toxin-Free Smart Technology Agricultural System (AgriTalk),” which integrates technologies such as biotechnology, AI, and the Internet of Things to provide functions including pest control and environmental monitoring. Encouraged by Jason Yi-Bing Lin, the then Vice President of NYCU, Prof. Chen, and the iGEM student team refined their prototype concept into a commercializable system and established the startup “AgriTalk” in 2019.

This group of students, forged through the iGEM competition, brought the spirit of initiative and proactively promoted themselves from the competition into the business world. Early in its startup journey, AgriTalk successfully invited the CTO of a major international corporation to visit its booth at CES in the U.S. with a precise one-minute presentation. “That year at the event, we generated approximately 1 billion dollars in business opportunities, with companies from over 30 countries expressing interest in having us set up manufacturing facilities there.” Although we can only precisely partner with a few companies due to their limited scale, Prof. Chen remains immensely proud of his students’ achievements in their first entrepreneurial venture.

Another project previously recognized by an iGEM grand award and made by Prof. Chen’s team is the “Smart Disease Detection Platform,” which employs an innovative technology that combines engineered bacteria with chips. This approach has not only significantly increased the biochip manufacturing yield—from less than 10% to over 90%—but also enables high-precision, rapid testing service for disease markers in pets. This technology has already attracted corporate partners to jointly collaborate, and the team is poised to formally enter the semiconductor and biomedical sensor markets through technology transfer and mergers and acquisitions.

“Be brave enough to take the leap and give it a try. No matter the outcome, one will gain a wealth of experience, and that will encourage one to venture into new fields in the future.” Prof. Chen’s words of encouragement to students eager to take on the iGEM challenge were concise yet powerful. In fact, Prof. Chen and the NYCU members, who once underwent the grueling “ordeal” of iGEM together, are the living embodiment of these words. For them, winning an iGEM award is not the end goal, but rather a fresh starting point for entering the industry, solving social problems, and changing the human world.

國際遺傳工程與機器設計競賽(iGEM)為全球最大規模的合成生物學學生競賽,每年吸引約300個團隊與會。2025年賽事中,國立陽明交通大學(NYCU)以「基因組整合生物磚平台(GenOMe)」勇奪金牌,並一舉獲得兩項特別獎提名。GenOMe運用如同樂高積木般的標準化組裝設計,同時輔以精密的數學模型預測,讓基因組整合技術的成功率,由0.2%大幅躍升至80%。

這意味著原本可能需要耗費半年到一年的菌種培育與篩選時間,未來將能縮短至數週甚至數天,在商業與臨床應用皆展現了極高的價值,獲得國際評審的高度讚譽。

以工程思維,解決生物問題

2013年起即擔任iGEM參賽領隊的陽明交大生物科技學系教授陳文亮指出,麻省理工學院(MIT)創辦iGEM,就是希望用工程的思維來解決生物研究所面臨的問題,期盼將基因如同積木般模組化後,即可依據研究目的排列組合,製造出具有特定功能、可執行特殊任務的「生物機器」。NVIDIA創辦人黃仁勳也曾公開表示,未來生物學將從「發現的科學(science of discovery)」朝向「工程的科學(science of engineering)」演進。

「其實Discovery存在某種浪漫與藝術的成分,但Engineering必須要有明確的目標。」陳文亮強調,陽明交大的iGEM參賽培訓過程中,老師不會主動提供答案,而是讓學生在訂定題目、尋求資源、問題解決等面向保有極大程度的主導權。

例如,原本團隊規劃將GenOMe修正並開發新的應用,作為2026年的參賽主題,但若學生臨時想換題目,陳文亮也會予以尊重:「即使時間上來不及,學生也要負起責任。遺憾有時也是教育中不可或缺的一環」。

專案導向學習,知識爆炸時代解方

NYCU的iGEM團隊成員背景多元,2025年團隊就由18位生物科技學系、電機工程學系、醫學系、醫學生物科技暨檢驗學系、資訊工程學系等大一學生組成。「最困難的是數學建模,這無法由資工背景的學生單獨完成,GenOMe的方程式就是由生技、醫學和資工系的成員共同完成。」陳文亮表示。

這種專案導向學習(Project-Based Learning, PBL)的訓練,學生在解題過程中若發現自己對於實驗方法、數學建模等技能有所不足,就必須主動學習以補足相關的基礎科學知識。陳文亮補充:「AI創造內容的速度太快,在這個知識快速膨脹與AI高速發展的時代,學生更要學會設定目標,才能有效率地篩選出真正需要的內容!」

特別值得一提的是,2023年團隊甚至是由人文社會學院學生擔任隊長,並引入了「生物藝術(BioArt)」的概念,將工程菌結合RGB三原色繪製出各式圖樣,更舉辦了線上畫展與專家演講。「在硬邦邦的工程和生物之中,結合了柔性的元素,完全顛覆了既有對於生物與工程的想像!」陳文亮笑著說道。
 

積極主動的種子,終將開花結實

此外陳文亮觀察到,iGEM極度重視「人文實踐整合(Integrating Human Practices)」的賽制設計,對於教育也極具啟發性。「這個賽制的設計概念,就是要讓團隊證明自己的技術對於社會和產業有沒有實質貢獻。」他進一步解釋,如果將參賽主題當成新創公司的產品來看,學生在研發期就要嘗試與其他研究者、業界人士接觸,不僅藉此了解對方的真實需求,並藉此修正研發方向,還要讓對方認可你的研究概念與價值。

「我們曾有學生從新竹騎著機車到台中農試所,與研究員討論預測模型準確性。有人則親自寫信邀請中研院的所長接受訪談。不只是研究單位,學生連企業都會自己去接洽。」陳文亮回憶,如果學生邀請函內容不到位,邀訪過程難免受挫,這時老師們才會出手指導學生修正邀訪流程。「只要能在學生心中種下積極主動的種子,總有一天學生在社會上發光發熱的能量會很不一樣。」

至於正式發表參賽主題之前,他會協助學生持續精進英文口說能力,目標要能在3至5分鐘內說明參賽主題的特點。「在iGEM發表會場中也不能呆坐著等人上門,我也告訴學生必須主動出擊,邀請其他學校學生或評審來參觀NYCU攤位。」陳文亮對於iGEM團隊成員的嚴格要求,終於在學生運用得獎主題創業時,開出美麗的花朵。

勇敢大步嘗試,開創無限可能

2014年起,陳文亮團隊便以整合生物科技、AI、物聯網等技術,具有害蟲防治與環境監控等功能的「無毒智慧科技農業系統(AgriTalk)」為主題,連續多年獲得iGEM多項大獎肯定。在時任交大副校長林一平的鼓勵下,陳文亮與iGEM團隊學生將原型概念修正為可商業化的系統後,於2019年成立了新創公司「農譯科技(AgriTalk)」。

這群歷經iGEM洗禮的學生,將比賽時主動出擊、積極自我行銷的精神帶到了商場。農譯科技創業之初,就曾在美國CES展上,以1分鐘的精準簡報成功邀請大型國際企業技術長到訪攤位。「那一年在會場中,我們創造出約10億美元的商機,30多國的業者都希望我們能去建廠。」雖然礙於公司規模,只能精選幾家合作業者,陳文亮對於學生首度創業的成績,仍相當引以為傲。

陳文亮團隊另一項曾獲得iGEM大獎肯定的「智慧疾病檢測平台」,在運用工程菌與晶片結合的創新技術後,不僅將原本低於10%的生物晶片製程良率大幅提升至90%以上,更可針對寵物疾病因子提供高精度、快速檢測服務。這項技術目前也已吸引企業共同合作,即將透過技術轉移與併購等模式,正式進軍半導體與生醫感測器市場。

「要勇敢地跨出去嘗試,無論結果如何,都能夠得到很多經驗,未來才有勇氣去跨足更多領域。」對於有心接受iGEM挑戰的學子們,陳文亮的勉勵簡潔而有力。事實上,陳文亮和曾經共同接受iGEM殘酷「洗禮」的NYCU成員們,正是這段話的最佳實踐者。對他們而言,iGEM奪獎並不是終點,而是跨入產業、解決社會問題與改變人類世界的嶄新起點。

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