• Contact
  • Education
  • Research Interest
  • Experiences
  • Awards and Honors
  • Publications
Muh Hwa Yang
Current Position
Contact
  • Phone

    (02) 2826-7000 ext. 67911/66510

  • Fax

    (02) 2823-5870

  • Email

    mhyang2@vghtpe.gov.tw;mhyang2@nycu.edu.tw

  • Address

    Street: No.155, Section 2, Li-Nong St. Beitou Dist. Room203, Shouren Building,Taipei 11221, Taiwan Institute of Clinical Medicine, National Yang-Ming University

  • Ph.D., Institute of Clinical Medicine, National Yang-Ming University, Taiwan (2003-2006)
  • M.D., Faculty of Medicine, National Yang-Ming University, Taiwan (1987-1994)
  • Cancer biology (molecular mechanism of cancer metastasis)
  • Clinical oncology (treatment for head and neck cancer)
  • Medical Oncology
  • Hematology
  • Internal medicine
  • Head and Neck cancer
  1. Vice President, National Yang-Ming University (2017/12/29-2021/01/31)
  2. Chair Professor, Institute of Clinical Medicine, National Yang Ming University School of Medicine (2016/08/01-present)
  3. Acting Director, Institute of Clinical Medicine, National Yang-Ming University (2017/07/16-2018/07/15)
  4. Director, Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital 2015/11/01-present)
  5. Director, Cancer Progression Center of Excellence, National Yang-Ming University (2014/08/01-present)
  6. Adjunct Research Fellow, Genomic Research Center, Academia Sinica (2014/08/01-present)
  7. Director, Immunity and Inflammation Research Center, National Yang-Ming University, Taipei, Taiwan (Aug 2013~Dec 2016)
  8. Professor, Institute of Clinical Medicine, National Yang Ming University School of Medicine, Taipei, Taiwan (Aug 2013~Jul 2016)
  9. Attending Physician, Division of Hematology-Oncology, Department of Medicine, Taipei Veterans General Hospital, Taiwan (Sep 2002~ Mar 2015)
  1. Outstanding Research Award, Ministry of Science and Technology科技部傑出研究獎 (2013-2015, 2016-2018)
  2. First prize of Distinguished Thesis, Taipei Veterans General Hospital台北榮民總醫院醫師學術論文獎第一名 (2009, 2011, 2013, 2015,2018,2019,2020)
  3. Excellent Doctor Award, Veterans Affairs Council行政院退除役官兵輔導委員會優良醫師獎 (2015)
  4. Outstanding Research Award, The Chinese Society of Immunology中華民國免疫學會傑出論文獎 (2015)
  5. Bio-medical Technology, 13th Y. Z. Hsu Scientific Paper Award徐有庠科技論文獎 (2015)
  6. Chien-Tien Hsu Outstanding Cancer Research Award, The Chinese Oncology Society中華民國癌症醫學會徐千田博士傑出研究獎 (2015)
  7. Award for Junior Research Investigators, Academia Sinica中央研究院年輕學者研究著作獎(生命科學組)(2011)
  8. Young Scientist Research Award, Tien-Te Lee Biomedical Foundation, Taiwan第六屆永信李天德基金會醫藥科技獎之青年科學家研究獎助金 (2011)
  9. Dr. Ta-Cheng  Tung  Memorial  Award  for  Basic  Cancer  Research,  Chinese Oncology Society, Taiwan中華民國癌症醫學會董大成博士基礎癌症醫學研究獎 (2009)
  10. Ta-Yu Wu Memorial Award, National Science Council 行政院國科會吳大猷先生紀念獎 (2008)
  • Selected Publication List
  1. Liao TT, Lin CC, Jiang JK, Yang SH, Teng HW, Yang MH*. Harnessing stemness and PD-L1 expression by AT-rich interaction domain-containing protein 3B in colorectal cancer. 2020 May 15;10(14):6095-6112.
  2. Yan X, Cao N, Chen Y, Lan HY, Cha JH, Yang WH*, Yang MH*. MT4-MMP promotes invadopodia formation and cell motility in FaDu head and neck cancer cells. Biochem Biophys Res Commun. 2020 Feb 19;522(4):1009-1014. (*: co-corresponding author)
  3. Li CF, Chen JY, Ho YH, Hsu WH, Wu LC, Lan HY, Hsu DS, Tai SK, Chang YC*, Yang MH*. Snail-induced claudin-11 prompts collective migration for tumour progression. Nat Cell Biol. 2019 Feb;21(2):251-262. (*: co-corresponding author)
  4. Lee CC, Lin JC, Hwang WL, Kuo YJ, Chen HK, Tai SK, Lin CC, Yang MH*. Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization. Nat Commun. 2018 Sep 14;9(1):3763. (*: corresponding author)
  5. Pan YR, Chen CC, Chan YT, Wang HJ, Chien FT, Chen YL, Liu JL, Yang MH*. STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas. Nat Commun. 2018 Sep 12;9(1):3696. (*: corresponding author)
  6. Hsieh CH, Tai SK, Yang MH*. Snail-overexpressing Cancer Cells Promote M2-Like Polarization of Tumor-Associated Macrophages by Delivering MiR-21-Abundant Exosomes. Neoplasia. 2018 Jul 2;20(8):775-788. (*: corresponding author)
  7. Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK, Hung MC, Yang MH*. Lymphotoxin-beta interacts with methylated EGFR to mediate acquired resistance to cetuximab in head and neck cancer. Clin Cancer Res. 2017 Aug 1;23(15):4388-4401. (*: corresponding author).
  8. Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH*. let-7 modulates chromatin configuration and target gene repression through regulation of the ARID3B complex. Cell Rep. 2016;14:520-533. (*: corresponding author).
  9. Hsu DS, Wang SJ, Tai SK, Chou CH, Hsieh CH, Chiu PH, Chen NJ, Yang MH*. Acetylation of Snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages. Cancer Cell 2014;26:534-548 (*:corresponding author).
  10. Hwang WL, Jiang JK, Yang SH, Huang TS, Lan HY, Teng HW, Yang CY, Tsai YP, Lin CH, Wang HW*, Yang MH*. MicroRNA-146a directs the symmetrical division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 2014;16:268-280 (*: co-corresponding authors).
  11. Yang WH, Lan SY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH*. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol. 2012; 14: 366-374 (*: corresponding author).
  12. Yang MH*, Hsu DS, Wang HW, Wang SJ, Lan HY, Yang WH, Huang CH, Kao SY, Tzeng CH, Tai SK, Chang SY, Lee OK, Wu KJ*. Bmi1 is essential in Twist1-induced epithelial-mesenchymal transition. Nat Cell Biol. 2010; 12:982-992 (*: corresponding author).
  13. Yang MH*, Wu MZ, Chiou SH, Chen PM, Chang SY, Liu CJ, Teng SC, Wu KJ. Direct regulation of TWIST by HIF-1alpha promotes metastasis. Nat Cell Biol 2008; 10:295-305.